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Explore how you can develop your career and bring your creative ideas to life at IFF. 2008-2023 ChemPoint. Avicel PC 611 (FMC Biopolymer) Supplied by. (&E. This Microcrystalline Cellulose . : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Quantity: 1 700 kgs. Avicel Microcrystalline Cellulose Physical Properties. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. MATERIAL SAFETY DATA SHEET Version: 1.0 1. }o]X4]. Microcrystalline Cellulose Side Effects. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. stream Synergies to simplify formulation challenges and reduce operational costs. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. However, consumption of large quantities of the material may have a laxative effect. 6 The table below shows the most common physicochemical parameters of this raw material. Molecular Weight null. 8 0 obj % Safety Data Sheet for Cellulose microcrystalline 102331. No. endobj 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Revision No. stream Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Manufacturer: FMC BioPolymer. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 1 0 obj $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. <> Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. SDS. endobj All Rights Reserved. CoA. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Microcrystalline Cellulose / Avicel PH-102. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. 2021 Annual Report. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Watch Now. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Terms and Conditions Compliance Solutions Industries About 3E News & Events . If breathing is difficult or if . on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. It is a white, free-flowing powder. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. It is also inert and biocompatible. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Aqueous suspensions of microcrystalline cellulose have . The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. << We respect your privacy FMC Privacy Policy. Performing this action will revert the following features to their default settings: Hooray! Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL POLYOX resins are nonionic polyethylene oxide solubility polymers. Microcrystalline Cellulose (MCC) MSDS 1. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. SUBSTANCE IDENTIFICATION 1.1. MATERIAL SAFETY DATA SHEET. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Browse Avicel PH-101 and related products at MilliporeSigma. It is . MSDS Ref. MATERIAL SAFETY DATA SHEET. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Eur., JPE . These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Find answers in our support articles. Are you sure you want to delete your template? However, if handling bulk powders, observance of appropriate safeguards is recommended. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. : 5. Home. ( Production of Pharmaceutical Grade Microcrystalline Cellulose. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. w !1AQaq"2B #3Rbr Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. The figure below illustrates the structural organisation of cellulose within plants. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). lH5JWy}DgKRR"Fs Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. ( The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. >> EINECS #: 232-674-9 1.7. A family of polysaccharide products that allow distinctive drug delivery solutions. Wu, K. Zuurman, H.W. <> Some substance identifiers may have been claimed confidential, or may . Magazine: Material safety data sheet - FMC Corporation. Product Name Cellulose microcrystalline. BIOACCUMULATIVE POTENTIAL Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. << PharmaCentral 2021 . Avicel PH-101. SCMm_>x^O9l (n. Quick Links. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Validity Area. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Your file is uploaded and ready to be published. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Regulatory Information Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization.
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